![]() Enormous implications of permanent chromosomal change and long-term constitutive Spike synthesis driving the pathogenesis of a whole new genre of chronic diseases. Side-by-side important reports reverse transcription, nuclear DNA code for Spike, both significant discoveries. ![]() This has become a crime against humanity. YOU MUST TAKE YOUR VACCINE OR ELSE!! Two days ago there was a story about a healthy 37-year-old who got the injection and suffered a heart attack almost immediately and then died two days later. What a study!! And, of course, VAERS data is being sabotaged. So, they found that the “spike protein” ALONE is “harmful to human cardiac cells.”Īnd what does the CoVid vaccine do? It injects mRNA so that cells, in which the mRNA finds itself, will PRODUCE ONLY the “spike protein.” The rest of the virus is not injected. Interestingly, the team found that antibodies blocking CD147-a receptor for the spike protein-protected heart pericytes from damage. The spike protein made pericytes unable to interact with their companion endothelial cells and induced them to secrete inflammatory cytokines, suggesting the spike protein is harmful to human cardiac cells. Intrigued by this finding, in a second test-tube experiment, the researchers challenged the cardiac pericytes with the spike protein alone, without the virus. Surprisingly, they found the heart pericytes were not infected. Now, listen to this:Ī research team led by Bristol’s Professor Paolo Madeddu exposed human heart pericytes, which are cells that wrap small blood vessels in the heart, to SARS-CoV-2 Alpha and Delta variants, along with the original Wuhan virus. This press release and linked paper can be found. ![]() We are left with several hypotheses and more questions, but with a clear direction.Share Facebook Twitter LinkedIn Flipboard Print arroba Email Indeed, presence of viral proteins has been associated with hyperinflammatory responses such as in severe COVID-19 or the notorious multisystem inflammatory syndrome in children (MIS-C). Given myocarditis also occurs after other vaccines, it is likely that the presence of circulating spike is a biomarker rather than the causal agent. The implications of this finding are unclear, since it is yet unknown how the spike protein evades cleavage or clearance, especially in the setting of a normal adaptive immune response, or whether in itself is pathogenic. Patients who developed postvaccine myocarditis had persistently elevated free spike protein in circulation, which correlated with evidence of cardiac injury and inflammatory cytokines. In summary, the data show that adaptive and T-cell immunity responses were normal in recipients of mRNA vaccines, both with and without myocarditis. The investigators used a thorough approach in teasing out the various aspects that could underlie vaccine-induced myocarditis. This is a great example of a study with mostly negative findings which are, however, insightful. However, inflammatory cytokine levels were altered, with elevations in interleukin (IL)-8, IL-6, tumor necrosis factor-alpha, IL-10, interferon-gamma and IL-1-beta, reflecting innate inflammatory activation. There were no differences in antibody levels (anti-spike, anti-receptor binding protein, immunoglobulin M, IgG, IgA, or anti-Fc), auto-antibodies, or antibodies to common respiratory pathogens. With regard to T-cell responses, there were no major differences in various T-cell subsets (effector, effector memory, spike-specific, interferon-gamma and degranulating). Levels of free spike did not differ between males and females, and remained elevated for weeks in a subset of patients with repeated blood collections. Levels of full-length spike protein (33.9 ± 22.4 pg/mL), unbound by antibodies were markedly elevated in the plasma of individuals with postvaccine myocarditis, whereas no free spike was detected in asymptomatic vaccinated control subjects (unpaired t-test p < 0.0001). Total neutrophil count was higher in patients with myocarditis compared to those without, albeit remaining in the normal range. All patients had elevated cardiac troponin T levels (median 260 ng/L) and C-reactive protein levels (29.75 mg/L). The cohort of myocarditis patients consisted of mostly males (n = 13 of 16) who experienced myocarditis after the second dose (n = 12 of 16), within the first week after vaccination (median of 4 days).
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